Acemetacin EP Impurity E with high purity CAS 75302-98-6 CAS NO.75302-98-6

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Product Name: Acemetacin EP Impurity E

Chemical Name: 2-(tert-butoxy)-2-oxoethyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Molecular Formula: C25H26ClNO6

Molecular Weight: 471.93

CAS#: 75302-98-6

Purity: 95%

Price: Negotiable

Available Document: COA, HPLC/GC, HNMR, qNMR, MS Spectrum

Payment Term: Payment in advance by T/T.

Shipment: Package usally dispatched in 7-15 days(According to the date of payment) by air.

Trade Term: EXW, FOB, CFR, DDU, DDP, ect.

Acemetacin EP Impurity E is an impurity of Acemetacin. Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin.[1] In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.6 It was developed by E. Merck and Company in Germany as an attempt to provide a safer drug but other than the amelioration on the gastrointestinal effects, the metabolism of acetamicin led to the formation of indomethacin and it kept the same side effects.[2]

Acemetacin is a non-selective inhibitor of the production of pro-inflammatory mediators derived from the action of the enzyme COX. COX is essential for the synthesis of prostaglandin E2 and F2 which are molecules derived from fatty acids and stored in the cell membrane.[3] Acetometacine is metabolized and forms its major metabolite indometacin which is also a non-selective inhibitor of COX and exhibits the capacity to inhibit the motility of polymorphonuclear leukocytes and decreased cerebral flow by modulating the nitric oxide pathway and vasoconstriction.[2]