Abacavir EP Impurity F with high purity(>98%) in stock CAS 1443421-68-8 CAS NO.1443421-68-8

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Product Name: Abacavir EP Impurity F

Chemical Name: 9-((1R,4S)-4-(tert-butoxymethyl)cyclopent-2-enyl)-N6-cyclopropyl-9H-purine-2,6-diamine

Molecular Formula: C18H26N6O

Molecular Weight: 342.44

CAS#: 1443421-68-8

Purity: >98%

Appearence: Off-White Solid

Price: Negotiable

Available Document: COA, HPLC/GC, HNMR, qNMR, MS Spectrum

Payment Term: Payment in advance by T/T.

Shipment: Package will dispatched in 7-15 days(According to the date of payment) by air.

Trade Term: EXW, FOB, CFR, DDU, DDP, ect.

N6-Cyclopropyl-9-[(1R,4S)-4-[(1,1-dimethylethoxy)methyl]-2-cyclopenten-1-yl]-9H-purine-2,6-diamine (Abacavir EP Impurity F) is an impurity of Abacavir (A104990), a guanosine analog that inhibits reverse transcriptase (NRTI) (1,2). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (3). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (4). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Reference:

(1) Hanumegowda, U., et al.: Chem. Res. Toxicol., 23, 749 (2010)

(2) Prasse, C., et al.: Environ. Sci. Technol., 44, 1728 (2010)